Keith, Author at INESEN BIO

Recombinant Collagen: A Breakthrough in Biotechnology

By KeithNew trendsNo Comments

Collagen is the most abundant protein in the human body, playing a vital role in providing structural support to connective tissues such as skin, tendons, and bones. Traditionally, collagen has been harvested from animal sources like cows or pigs, raising concerns about zoonotic disease transmission, ethical considerations, and immunogenicity. The advent of recombinant human collagen (RhC) offers a groundbreaking alternative, combining safety, ethical production, and consistent quality.

What is Recombinant Human Collagen?

Recombinant human collagen is produced using genetic engineering. Scientists insert human collagen-encoding genes into host organisms—such as bacteria, yeast, or even plants—which then express the protein during their growth. This method ensures that the produced collagen is structurally identical to naturally occurring human collagen, eliminating the risk of immune reactions often associated with animal-derived proteins.

Production Process

The production of Rh Collagen involves several key steps:

Gene Cloning: Human collagen genes are identified and isolated. These genes are then inserted into a vector, a carrier molecule used to introduce the genes into the host organism.
Expression in Host Organisms: Common hosts for recombinant protein production include Escherichia coli, yeast species like Pichia pastoris, and plants like tobacco or corn. Each host offers unique advantages in yield, cost, and scalability.
Purification: After the host organism synthesizes collagen, the protein is extracted and purified to remove impurities. Advanced purification techniques ensure high-quality collagen suitable for various applications.
Modification and Assembly: Collagen molecules may require post-translational modifications, such as hydroxylation of proline residues, to achieve their functional triple-helical structure.

Advantages of Recombinant Human Collagen

Compared to traditional animal-derived collagen, RhC offers several benefits:

Safety: Free from animal pathogens, reducing the risk of disease transmission.
Ethical: Eliminates the need for animal farming and slaughter, aligning with vegan and cruelty-free principles.
Consistency: Production in controlled environments ensures uniform quality and reduced batch variability.
Customization: Genetic engineering allows tailoring the collagen structure for specific applications.

The unique properties of RhC, such as biocompatibility and safety, have opened doors to a wide range of applications in cosmetic industry. RhC is a key ingredient in anti-aging creams, serums, and injectable fillers, providing improved hydration and elasticity to the skin. Its human origin reduces allergic reactions compared to animal-derived alternatives. One of the best examples of the products are Neotiva and Karisma.

Neotiva Rh Collagen is a new injectable collagen in composition with succinic acid, polynucleotides and hyaluronic acid. It’s known for its safety and immediate results. It revitalizes the skin of the face, neck, decolletage, & hands promoting a more youthful and radiant complexion & minimizes the appearance of scars and stretch marks. It enhances the facial contours with a subtle lifting effect & reduces the appearance of fine lines & wrinkles, resulting in youthful-looking skin.
Karisma Rh Collagen is an injectable – MD Class III, re-absorbable and bio-replenishing medical device. It is guaranteed by a studied and calibrated dosage of its ingredients allowing a long lasting and prolonged effect to a novel patented natural human collagen precursor (collagen polypeptidic α 1 chain R) promotes the production of type I collagen in dermal human fibroblasts.

Conclusion

Recombinant human collagen is revolutionizing multiple industries by providing a safe, ethical, and high-quality alternative to animal-derived collagen. Its versatility in medical, cosmetic, and industrial applications underscores its significance as a cornerstone of modern biotechnology. As research progresses, RhC is poised to become a pivotal player in advancing healthcare and sustainability.

December 9, 2024

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Benefits and Uses of PLLA in Aesthetic medicine

By KeithCollagen stimulator

In the rapidly evolving world of aesthetic medicine, new advancements continually emerge, offering patients innovative solutions for skin rejuvenation and anti-aging. One such revolutionary material is PLLA (Poly-L-Lactic Acid), a biocompatible and biodegradable polymer that has garnered widespread attention for its impressive role in facial rejuvenation and other cosmetic applications.

What is PLLA?

Scientists derive Poly-L-Lactic Acid (PLLA) from lactic acid, a naturally occurring substance in the body. Its safe, non-toxic, and biodegradable properties have made it a popular choice for both medical and aesthetic purposes. Initially, PLLA was used in absorbable sutures and implants due to its biocompatibility, but over the past two decades, PLLA has significantly expanded it’s role in aesthetic medicine, particularly in volume restoration and skin rejuvenation treatments. One of the newest products in the market manufactured with latest technology is POLYFEEL.

How Does PLLA Work in Aesthetics?

PLLA’s primary function in aesthetic treatments is stimulating collagen production. Unlike traditional dermal fillers that provide instant volume by filling the skin, PLLA works by gradually stimulating the body’s natural collagen production over time. Collagen, a key structural protein in the skin, is essential for maintaining skin elasticity, volume, and firmness. As we age, collagen production decreases, leading to wrinkles, sagging skin, and volume loss. PLLA injections help reverse this process by encouraging the skin to rebuild its collagen stores, leading to a more youthful and refreshed appearance.

Once injected into the deeper layers of the skin, PLLA microparticles act as a scaffold, promoting fibroblast activity and collagen production over several months. As the body metabolizes the PLLA, the newly generated collagen provides volume and firmness to the treated areas, offering results that can last up to two years or more.

Uses and Applications of PLLA in Aesthetic Medicine

PLLA has been primarily recognized for its use in the injectable treatment for restoring facial volume lost due to aging or illness. Beyond facial rejuvenation, practitioners also use PLLA in a variety of other cosmetic applications.:

Facial Volume Restoration: PLLA is highly effective for treating hollow cheeks, deep nasolabial folds, and marionette lines. By stimulating collagen growth, PLLA helps to restore lost volume and smooth out deep wrinkles and folds over time.
Hand Rejuvenation: We use PLLA to improve the appearance of aging hands by restoring volume and reducing the visibility of veins and tendons.
Body Contouring: PLLA is also used in certain body contouring treatments, including addressing sagging skin in areas like the knees, arms, and abdomen, improving skin texture and tone through collagen stimulation.

Key Benefits of PLLA

PLLA offers several unique benefits compared to traditional fillers or other rejuvenation treatments:

Natural-Looking Results: Since PLLA gradually stimulates collagen production, the results appear progressively over time, creating a subtle and natural improvement in volume and skin quality.
Long-Lasting Effects: PLLA treatments offer long-lasting results, with many patients enjoying benefits for up to two years or more after a series of treatments.
Non-Invasive and Minimal Downtime: PLLA injections are minimally invasive and require little to no downtime, making them an attractive option for patients looking for effective yet convenient treatments.
Improved Skin Quality: Beyond volume restoration, PLLA enhances overall skin texture and tone by encouraging collagen growth, leading to firmer, smoother, and more youthful-looking skin.

What to Expect from a PLLA Treatment

The PLLA treatment process is straightforward. A trained healthcare provider will administer PLLA injections into the areas of concern, such as the cheeks, nasolabial folds. The treatment typically takes 30 to 45 minutes. Most patients require a series of treatments (usually three to four sessions spaced several weeks apart) to achieve optimal results.

Post-treatment, patients may experience mild swelling, redness, or bruising, which generally resolves within a few days. The results of PLLA develop gradually, so most patients begin to notice improvements within a few months as collagen production increases. The full effects typically become visible after six months.

Potential Side Effects

Like any cosmetic procedure, PLLA treatments may have side effects, though they are generally mild and temporary. Swelling, redness, tenderness, and bruising at the injection sites are common side effects. Rarely, patients may experience small lumps under the skin, though these can often be minimized by proper injection technique and post-treatment massage.

Conclusion

Practitioners have embraced PLLA (Poly-L-Lactic Acid) as a powerful tool in aesthetic medicine. It offers patients a non-invasive, long-lasting solution to facial volume loss, skin aging, and body contouring. PLLA treatments actively stimulate the body’s natural collagen production, delivering gradual, natural-looking results. These long-lasting effects make PLLA a popular choice for individuals seeking subtle and effective rejuvenation. Whether it’s restoring facial volume, enhancing body contours, or revitalizing aging skin, PLLA is proving to be a versatile and reliable option in the pursuit of beauty and youthfulness.

October 2, 2024

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Introducing Invenio: The Name Behind the Innovation!

By KeithDermal fillers

Hey everyone! 👋 We’re thrilled to share the inspiration behind the name of our dermal filler: Invenio. Every name has a story, and Invenio perfectly captures what our product is all about. Here’s why we chose this name and what it represents:

🔍 Discovery and Innovation:
“Invenio” is derived from the Latin word meaning “to discover” or “to find.” This name embodies our commitment to uncovering the best in science and nature to bring you groundbreaking solutions. After all we are dedicated to the relentless pursuit of innovation, constantly seeking new ways to enhance your beauty and well-being.

💡 Breakthrough Technology:
Invenio represents our cutting-edge technology and pioneering approach. We strive to create products that not only meet but exceed your expectations, setting new standards in the industry. Thus, we designed our innovative formulas to deliver exceptional results, helping you discover your true potential.

Invenio dermal fillers: Soft / Kiss/ Deep / Volume

🌸 Unveiling Your Natural Beauty:
At the heart of Invenio is the belief that everyone has their own unique beauty waiting to be revealed. Therefore, our fillers are crafted to enhance and celebrate your natural features, bringing out the best version of you. As we believe, it’s all about discovery and transformation!

🌟 Our Promise:
With Invenio, we promise a filler that is not only effective but also safe and gentle. We are undeniably committed to using high-quality, sustainable ingredients that work in harmony with your body.

Trust in Invenio to deliver results you can see and feel!

July 22, 2024

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Biotin and Hair Loss: Exploring the Connection

By KeithAbout hair

Hair loss is a common concern for many individuals, impacting both men and women of various ages. Amidst the multitude of treatments and supplements marketed for hair health, biotin has emerged as a popular option. But what exactly is biotin, and how does it relate to hair loss? Let’s delve into the science behind biotin and its potential role in addressing hair loss.

Understanding Biotin:

Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin that plays a crucial role in various bodily functions, including metabolism, cell growth, and the production of fatty acids. It is an essential cofactor for several enzymes involved in carbohydrate, fat, and protein metabolism.

Biotin and Hair Health:

The relationship between biotin and hair health has garnered significant attention, particularly in the context of hair loss. Hair follicles require a constant supply of nutrients to support healthy growth, and deficiencies in key vitamins and minerals can contribute to hair thinning and loss.

Biotin is believed to promote hair growth and overall hair health through its involvement in keratin production. Keratin is a fibrous protein that forms the structural foundation of hair, skin, and nails. Since biotin is essential for keratin synthesis, adequate levels of this vitamin are crucial for maintaining strong, resilient hair strands.

The Evidence:

While anecdotal reports and marketing claims often tout the benefits of biotin for hair growth, scientific evidence supporting its efficacy in treating hair loss is somewhat limited. Several small-scale studies and case reports have suggested a potential link between biotin deficiency and hair loss. However, larger clinical trials are needed to establish a definitive connection and determine the optimal dosage and treatment duration.

One study published in the Journal of Clinical and Aesthetic Dermatology found that supplementation with biotin, along with other vitamins and minerals, led to significant improvements in hair growth and thickness among women with thinning hair. However, more research is needed to confirm these findings and elucidate the mechanisms underlying biotin’s effects on hair health.

Biotin Deficiency and Hair Loss:

Biotin deficiency is rare but can occur in individuals with certain underlying medical conditions or dietary restrictions. Symptoms of biotin deficiency may include hair loss, along with skin rashes, brittle nails, and neurological symptoms such as depression and fatigue.

In cases where hair loss is attributed to biotin deficiency, supplementation with biotin may help restore hair growth and reverse the associated symptoms. However, it’s essential to consult with a healthcare professional before starting any supplementation regimen, as excessive intake of biotin or other vitamins can have adverse effects.

Conclusion:

Biotin is an essential nutrient that plays a vital role in maintaining healthy hair, skin, and nails. While biotin supplementation may benefit individuals with biotin deficiency-related hair loss, more research is needed to fully understand its efficacy in treating other forms of hair loss. Additionally, addressing underlying factors contributing to hair loss is key for achieving optimal outcomes in hair restoration and maintenance.

December 22, 2023

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